A	B	C
1	Main
2		Brand Name	Velcade, fka PS-341
3		Generic Name	bortezomib
4		Molecule	Boronic acid dipeptide
5		Mechanism	Proteasome inhibitor
6		Papers	A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma. Richardson et al. NEJM 348;26:2003
7		Safety	Thrombocytopenia, fatigue, neuropathy, neutropenia.
8		Market	15,000 new cases of multiple myeloma annually. 10,000 deaths.
9		Clinical Trials
10
11			Phase II NEJM n=193 evaluable
12			35% response rate. mOS 16 months.