A	B	C
1	Main
2		Brand Name	Symbicort
3		Mechanism	Combination LABA (formoterol is also fast acting 1-2 minutes) and corticosteroid
4		Administration	Inhaled - SMART variable dosing filed - allows patient to use 1-4 inhalations bid to prevent attacks - no second inhaler needed (second inhaler with salbutamol needed)
5			Turbuhaler device. Also developed as an MDI.
6		Indication	Asthma, COPD
7		Economics	100%, jointly promoting with Astellas in Japan.
8		Competition	Advair. Symbicort can be used to prevent as well as treat acute attacks.
9			Symbicort's formoterol has an onset of action of 5 minutes vs sameterol's 30-60 minutes.
10		Timeline	Launched 5/18/2007.
11		Clinical Trials	COSMOS - significant decrease in asthmatic exacerbations in patients using Symbicort SMART compared to Advair - 30% reduction
12			COMPASS - Symbicort reduced exacerbations 39% more than Advair and 28% more than fixed-dose Symbicort
13			SMILE
14			4 head-to-head trials of Symbicort vs Advair
15			SUND showed patient-controlled variability of dosing reduced exacerbations by 40% vs Advair