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| Patent | Title | Assignee | Inventors | Importance | Filed | Issued | Notes |
| 11390600 | Crystalline forms of C.sub.21H.sub.22Cl.sub.2N.sub.4O.sub.2 | Biomed Valley Discoveries, Inc. (Kansas City, MO); Vertex Pharmaceuticals Incorporated (Boston, MA) | DeCrescenzo; Gary (Parkville, MO), Welsch; Dean (Parkville, MO), Vlahova; Petinka I. (West Lafayette, IN), Boerrigter; Stephan X. M. (West Lafayette, IN), Aronov; Alexander (Newton, MA), Keshavarz-Shokri; Ali (San Diego, CA), Scangas; Alexander N. (Wilmington, MA), Stavropoulos; Kathy (Quincy, MA), Littler; Benjamin (Carlsbad, CA), Kadiyala; Irina Nikolaevna (Newton, MA), Alargova; Rossitza Gueorguieva (Brighton, MA) | 2 | 7/7/2020 | 7/19/2022 | Outlicensed ERK inhibitor |
| 11370798 | Compounds useful as inhibitors of ATR kinase | Vertex | Ahmad; Nadia (Didcot, GB), Boyall; Dean (Faringdon, GB), Charrier; Jean-Damien (Wantage, GB), Davis; Chris (Salisbury, GB), Davis; Rebecca (Witney, GB), Durrant; Steven (Abingdon, GB), Etxebarria I Jardi; Gorka (Abingdon, GB), Fraysse; Damien (Abingdon, GB), Jimenez; Juan-Miguel (Abingdon, GB), Kay; David (Purton, GB), Knegtel; Ronald (Abingdon, GB), Middleton; Donald (Sandwich, GB), O'Donnell; Michael (Abingdon, GB), Panesar; Maninder (Didcot, GB), Pierard; Francoise (Abingdon, GB), Pinder; Joanne (Didcot, GB), Shaw; David (Oxford, GB), Storck; Pierre-Henri (Abingdon, GB), Studley; John (Witney, GB), Twin; Heather (Wantage, GB) | 2 | 8/31/2020 | 6/28/2022 | ATR inhibitor |
| 11369692 | Materials and methods for treatment of Duchenne Muscular Dystrophy | Vertex | Kabadi; Ami Meda (Cambridge, MA), Cowan; Chad Albert (Cambridge, MA), Lundberg; Ante Sven (Cambridge, MA) | 5 | 10/28/2016 | 6/28/2022 | 2016?! CRISPR patent |
| 11358977 | Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels | Vertex | Jiang; Licong (San Diego, CA), Hadida Ruah; Sara Sabina (La Jolla, CA) | 8 | 5/16/2018 | 6/14/2022 | Nav1.8 |
| 11345700 | Methods of preparing inhibitors of influenza viruses replication | Vertex | Tanoury; Gerald J. (Marlborough, MA), Nugent; William Aloysius (Manomet, MA), Dvornikovs; Vadims (Lancaster, MA), Rose; Peter Jamison (Littleton, MA) | 1 | 3/9/2020 | 5/31/2022 | Why still filing on this post sale to JNJ? |
| 11291662 | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- -3-carboxamide | Vertex | Hurter; Patricia (Harvard, MA), Rowe; William (Medford, MA), Young; Christopher R. (Waltham, MA), Costache; Adriana (Cambridge, MA), Connelly; Patrick R. (Harvard, MA), Krawiec; Mariusz (Marlborough, MA), Gong; Yuchuan (Waukegan, IL), Feng; Yushi (Zionsville, IN), Trudeau; Martin (Shannon, CA) | 3 | 12/5/2019 | 4/5/2022 | Kalydeco |
| 11268077 | Materials and methods for treatment of hemoglobinopathies | Vertex | Chakraborty; Tirtha (Cambridge, MA), Mishra; Bibhu Prasad (Wakefield, MA) | 5 | 2/5/2019 | 3/8/2022 | CRISPR for HbF; where is CRSP? |
| 11253509 | Methods of treatment for cystic fibrosis | Vertex | Chen; Weichao George (San Diego, CA), Haseltine; Eric L. (Melrose, MA), Moskowitz; Samuel (Waban, MA), Robertson; Sarah (Somerville, MA), Waltz; David (Waban, MA) | 2 | 6/8/2018 | 2/22/2022 | |
| 11203571 | Sulfonamides as modulators of sodium channels | Vertex | Hadida-Ruah; Sara Sabina (LaJolla, CA), Anderson; Corey (San Diego, CA), Termin; Andreas P. (Encinitas, CA), Bear; Brian Richard (Carlsbad, CA), Arumugam; Vijayalaksmi (San Marcos, CA), Krenitsky; Paul (San Diego, CA), Johnson; James Philip (San Diego, CA) | 8 | 7/15/2014 | 12/21/2021 | Nav1.8 |
| 11186566 | Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator | Vertex | Alcacio; Timothy (San Diego, CA), Baek; Minson (San Diego, CA), Grootenhuis; Peter (Del Mar, CA), Hadida Ruah; Sara Sabina (La Jolla, CA), Hughes; Robert M. (San Diego, CA), Keshavarz-Shokri; Ali (San Diego, CA), McAuley-Aoki; Rachel (San Diego, CA), McCartney; Jason (Cardiff by the Sea, CA), Miller; Mark Thomas (San Diego, CA), Van Goor; Fredrick (San Diego, CA), Zhang; Beili (San Diego, CA), Anderson; Corey (San Diego, CA), Cleveland; Thomas (San Marcos, CA), Frieman; Bryan A. (La Jolla, CA), Khatuya; Haripada (San Diego, CA), Joshi; Pramod Virupax (San Diego, CA), Krenitsky; Paul John (San Diego, CA), Melillo; Vito (Escondido, CA), Pierre; Fabrice Jean Denis (La Jolla, CA), Termin; Andreas P. (Encinitas, CA), Uy; Johnny (San Diego, CA), Zhou; Jinglan (San Diego, CA), Abela; Alexander Russell (San Diego, CA), Busch; Brett Bradley (San Diego, CA), Paraselli; Prasuna (San Diego, CA) | 6 | 12/4/2019 | 11/30/2021 | CFTR |
| 11179394 | Method for treating cancer using a combination of Chk1 and ATR inhibitors | Vertex | Helleday; Thomas (Stockholm, SE), Sanjiv; Kumar (Stockholm, SE) | 3 | 6/17/2015 | 11/23/2021 | ATR/Chk1 MOU |
| 11179367 | Pharmaceutical compositions for treating cystic fibrosis | Vertex | Chu; Cathy (Cambridge, MA), Dhamankar; Varsha (Watertown, MA), Dokou; Eleni (Cambridge, MA), Haseltine; Eric L. (Melrose, MA), Moskowitz; Samuel (Waban, MA), Robertson; Sarah (Somerville, MA), Waltz; David (Waban, MA), Chen; Weichao George (San Diego, CA) | 2 | 2/4/2019 | 11/23/2021 | Formulation |
| 11155533 | Crystalline forms and compositions of CFTR modulators | Vertex | Dhamankar; Varsha (Watertown, MA), Dinehart; Kirk Raymond (Holliston, MA), Dokou; Eleni (Newton, MA), Ferris; Lori Ann (Wilmington, MA), Gopinathan; Nishanth (Lynnfield, MA), McCarty; Katie (Watertown, MA), Metzler; Catherine (Medford, MA), Zhang; Beili (San Diego, CA), Moskowitz; Samuel (Waban, MA), Robertson; Sarah (Somerville, MA), Waltz; David (Waban, MA), Haseltine; Eric L. (Melrose, MA), Chen; Weichao George (San Diego, CA) | 2 | 3/25/2020 | 10/26/2021 | Crystal |
| 11147770 | Pharmaceutical composition and administrations thereof | Vertex | Dokou; Eleni (Cambridge, MA), Jamzad; Shahla (Belmont, MA), Caesar, Jr.; John P. (Lancaster, MA), Fawaz; Majed (Foxboro, MA), Das; Laura (Charlestown, MA), Gu; Chong-Hui (Waban, MA), Hurter; Patricia Nell (Harvard, MA), Israni; Meghna Jai (Boston, MA), Johnston; Meghan M. (Wakefield, MA), Knezic; Dragutin (Watertown, MA), Kuzmission; Andrew G. (Shrewsbury, MA), Wang; Hongren (Lexington, MA) | 2 | 3/12/2019 | 10/19/2021 | Formulation |
| 11124805 | Methods, compositions and kits for increasing genome editing efficiency | Vertex | Abdul-Manan; Norzehan (Boston, MA), Newsome; David A. (Boston, MA), Zwahlen; Jacque (Boston, MA) | 7 | 7/13/2017 | 9/21/2021 | DNAPK inhibitor to increase CRISPR efficiency |
| 11117900 | Compounds useful as inhibitors of ATR kinase | Vertex | Ahmad; Nadia (Didcot, GB), Boyall; Dean (Faringdon, GB), Charrier; Jean-Damien (Wantage, GB), Davis; Chris (Salisbury, GB), Davis; Rebecca (Witney, GB), Durrant; Steven (Abingdon, GB), Etxebarria I Jardi; Gorka (Abingdon, GB), Fraysse; Damien (Abingdon, GB), Jimenez; Juan-Miguel (Abingdon, GB), Kay; David (Purton, GB), Knegtel; Ronald (Abingdon, GB), Middleton; Donald (Sandwich, GB), O'Donnell; Michael (Abingdon, GB), Panesar; Maninder (Didcot, GB), Pierard; Francoise (Abingdon, GB), Pinder; Joanne (Didcot, GB), Shaw; David (Oxford, GB), Storck; Pierre-Henri (Abingdon, GB), Studley; John (Witney, GB), Twin; Heather (Wantage, GB) | 3 | 8/6/2019 | 9/14/2021 | |
| 11110108 | Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors | Vertex | Boucher; Diane M. (Boston, MA), Hillier; Shawn M. (Boston, MA), Tsai; Wanjung (Boston, MA), Hare; Brian (Boston, MA), Markland; William (Boston, MA), Newsome; David A. (Boston, MA), Penney; Marina S. (Boston, MA) | 2 | 9/27/2017 | 9/7/2021 | |
| 11110086 | Compounds useful as inhibitors of ATR kinase and combination therapies thereof | Vertex | Pollard; John Robert (Abingdon, GB), Reaper; Philip Michael (Abingdon, GB), Asmal; Mohammed (Newton, MA) | 3 | 7/10/2019 | 9/7/2021 | |
| 11084804 | Modulators of ATP-binding cassette transporters | Vertex | Hadida Ruah; Sara S. (La Jolla, CA), Hamilton; Matthew M. (Hackettstown, NJ), Miller; Mark (San Diego, CA), Grootenhuis; Peter D. J. (San Diego, CA) | 5 | 2/13/2020 | 8/10/2021 | CFTR |
| 11066417 | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators | Vertex | Clemens; Jeremy J. (San Diego, CA), Abela; Alexander Russell (Escondido, CA), Anderson; Corey Don (San Diego, CA), Busch; Brett B. (San Diego, CA), Chen; Weichao George (San Diego, CA), Cleveland; Thomas (San Marcos, CA), Coon; Timothy Richard (Carlsbad, CA), Frieman; Bryan (La Jolla, CA), Ghirmai; Senait G. (San Diego, CA), Grootenhuis; Peter (Del Mar, CA), Gulevich; Anton V. (San Diego, CA), Hadida Ruah; Sara Sabina (La Jolla, CA), Hsia; Clara Kuang-Ju (San Diego, CA), Kang; Ping (San Diego, CA), Khatuya; Haripada (San Diego, CA), McCartney; Jason (Cardiff by the Sea, CA), Miller; Mark Thomas (San Diego, CA), Paraselli; Prasuna (San Diego, CA), Pierre; Fabrice (La Jolla, CA), Swift; Sara E. (San Diego, CA), Termin; Andreas (Encinitas, CA), Uy; Johnny (San Diego, CA), Vogel; Carl V. (Carlsbad, CA), Zhou; Jinglan (San Diego, CA) | 6 | 2/14/2019 | 7/20/2021 | |
| 11059826 | Pteridinone compounds and uses thereof | Vertex | Lauffer; David J. (Stow, MA), Bemis; Guy (Boston, MA), Boyd; Michael (Boston, MA), Deininger; David (Boston, MA), Deng; Hongbo (Southborough, MA), Dorsch; Warren (Boston, MA), Gu; Wenxin (Concord, MA), Hoover; Russell R. (Harvard, MA), Johnson, Jr.; Mac Arthur (Derry, NH), Ledeboer; Mark Willem (Boston, MA), Ledford; Brian (Boston, MA), Maltais; Francois (Boston, MA), Penney; Marina (Acton, MA), Takemoto; Darin (Belmont, MA), Waal; Nathan D. (Cambridge, MA), Wang; Tiansheng (Concord, MA), Li; Pan (Lexington, MA) | 5 | 4/23/2019 | 7/13/2021 | WFS1 inhibitor |
| 11052075 | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid and administration thereof | Vertex | Verwijs; Marinus Jacobus (Framingham, MA), Alargova; Rossitza Gueorguieva (Brighton, MA), Kaushik; Ritu Rohit (Long Island City, NY), Kadiyala; Irina Nikolaevna (Newton, MA), Young; Christopher (Waltham, MA) | | 8/2/2019 | 7/6/2021 | Formulation |