A	B	C	D	E
1	Main
2		Brand	VX-548
3		Generic
4		Indication	Pain
5		MOA	Nav1.8
6		Dosing	Loading dose with q12h thereafter
7		Clinical Trials
8			Phase III bunionectomy or abdominoplasty n=2000
9
10
11
12			Phase II n=274 dose-ranging bunionectomy
13				SPID48 change from baseline
14			Placebo	101
15			100mg first dose/50mg q12h	137.8	p=0.0251
16			60mg first dose/30mg q12h	86.9	p=NS
17			20mg first dose/10mg q12h	112.9	p=NS
18			hydrocodone	115.6	p=NS
19
20
21			Phase II n=303 dose-ranging abdominoplasty
22				SPID48 change from baseline
23			Placebo	72.7
24			100mg first dose/50mg q12h	110.5	p=0.0097
25			60mg first dose/30mg q12h	95.1	p=NS
26			hydrocodone	85.2	p=NS