A	B	C
1	Main
2		Brand Name
3		Generic Name	darusentan
4		Indication	Resistant Hypertension. 7 million drug-treated hypertensive patients on 3+ drug regimens. 2-3m in the US are resistant or uncontrolled. - GILD #s.
5		Safety	Peripheral Edema 7-12%.
6		Clinical Trials
7			Phase III - Study 311 - placebo-controlled study - 53% enrolled as of 4/2008
8			Patients who are resistant to 3 full doses of antihypertensives including a diuretic.
9			Will ammend protocol to reduce # of HTN drugs from 4 to 3.
10
11			Phase III - Study 312 - active comparator - n=770 - 17% enrolled as of 4/2008
12			First patients enroll 6/30/07
13			Darusentan vs guanfasine vs placebo 3:3:1
14
15			Phase II - Published in J of Clinical Hypertension 2007