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Main | | | | | | | | | | | | |
Failures | | | | | | | | | | | | |
| Brand Name | Generic Name | | Indication | Mechanism | Approval | Revenue | | | | | |
| Arthrotec | | | | | | 300m | | | | | |
| Celebrex | celecoxib | | Arthritis | COX-2 | 12/31/1998 | | | | | | |
| Cleocin | | | | macrolide | | 175m | | | | | |
| Covera HS | | | | | | | | | | | |
| Estring | | | | | | | | | | | |
| Fablyn | | | | | | | | | | | |
| Gelfilm | | | | | | | | | | | |
| Lyrica | pregabalin | | Epilepsy, Pain, FMS | GABA delta ligand | 12/30/2014 | | | | | | |
| | | | | | | | | | | | |
| | | | | | | | | | | | |
| Brand Name | Generic Name | Status | Indication | Mechanism | Phase | Results | | | | | |
| PD-332,334 | | | | | | | | | | | |
| S,S-reboxetine | | | | | | | | | | | |
| | torcetrapib | | | | | | | | | | |
| Exubera | | | | | | | | | | | |
| PEG HGH? | | | | | | | | | | | |
| CP-607,366 | | | | | | | | | | | |
| PNU-108112 | | | | | | | | | | | |
| PNU-93914 | | | | | | | | | | | |
| VIC-ACNE | | | | | | | | | | | |
| | | | | | | | | | | | |
| Edotecarin | | | | | | | | | | | |
| Camptosar | | | | | | | | | | | |
| CP-751,871 | | | | | | | | | | | |
| PF-514273 | | | | | | | | | | | |
| CE-326597 | | | | | | | | | | | |
| PF-3185043 | | | | | | | | | | | |
| CP-800569 | | | | | | | | | | | |
| PF-3392455 | | | | | | | | | | | |
| PF-277343 | | | | | | | | | | | |
| PF-04548043/KOS-2187 | | | | | | | | | | | |
| CP-424,391 (capromorelin) | | | | | | | | | | | |
| PF-885706 | | | | | | | | | | | |
| PF-708093 | | | | | | | | | | | |
| PF-4522625 | | | | | | | | | | | |
| PF-572778 | | | | | | | | | | | |
| PF-477736 | | | | | | | | | | | |
| PF-3814735 | | | | | | | | | | | |
| PF-562271 | | | | | | | | | | | |
| CVX-045 | | | | | | | | | | | |
| PF-337210 | | | | | | | | | | | |
| PF-3,732,010 | | | | | | | | | | | |
| PF-04217903 | | | | | | | | | | | |
| UK 396082 | | | | | | | | | | | |
| SNX5422/PF-04929113 | | | | | | | | | | | |
| CP-870893 | | | | | | | | | | | |
| PF-3557156 | | | | | | | | | | | |
| CP-601927 | | | | | | | | | | | |
| PF-3463275 | | | | | | | | | | | |
| PF-2400013 | | | | | | | | | | | |
| CP-903397 | | | | | | | | | | | |
| PF-04447943 | | | | | | | | | | | |
| PF-592379 | | | | | | | | | | | |
| PF-04191834 | | | | | | | | | | | |
| PF-4136309 | | | | | | | | | | | |
| PF-4480682 | | | | | | | | | | | |
| PF-4523655 | | | | | | | | | | | |
| AG-13958 | | | | | | | | | | | |
| CP-675206 | | | | | | | | | | | |
| SU-14813 | | | | | | | | | | | |
| PF-1367338/AG-014699 | | | | | | | | | | | |
| PF-4494700 | | | | | | | | | | | |
| CP-448187 (elzasonan) | | | | | | | | | | | |
| PD-200,390 | | | | | | | | | | | |
| PD-299,685 | | | | | | | | | | | |
| PF-04360365 | ponezumab | | | | | | | | | | |
| PF-232798 | | | | | | | | | | | |
| UK-369003 | | | | | | | | | | | |
| PF-217830 | | | | | | | | | | | |
| PF-03654746 | | | | | | | | | | | |
| PF-3491390 | | | | | | | | | | | |
| UK-157147 | | | | | | | | | | | |
| PF-275366 | | | | | | | | | | | |
| PH-794428 | | | | | | | | | | | |
| CP-533536 | | | | | | | | | | | |
| PF-610355 | | | | | | | | | | | |
| UK-453061 (lersivirine) | | | | | | | | | | | |
| | | | | | | | | | | | |
| Withdrawn/Failed | | | | | | | | | | | |
| Figitumumab | | | | | | | | | | | |
| Tanezumab | | | | | | | | | | | |
| Torcetrapib | | | | | | | | | | | |
| Rezulin | | | | | | | | | | | |
| Trovan | | | | | | | | | | | |
| Bextra - suspended in 2005. Peaked at $1.3bn. | | | | | | | | | | | |
| SU-6888 | | | | | | | | | | | |
| cdk2/cdk4 | | | | | | | | | | | |
| AG-2037 | | | | | | | | | | | |
| CJ-23,423 | | | | | | | | | | | |
| VIC-5555 | | | | | | | | | | | |
| Thelin | | | | | | | | | | | |
| SU-14,813 | | | | | | | | | | | |
| PF-00708093 oxazolidinone | | | | | | | | | | | |
| UK-464,273 | | | | | | | | | | | |
| canertinib/CI-1033 | | | | | | | | | | | |
| CI-1040 (MEK) | | | | | | | | | | | |
| FGF-14 | | | | | | | | | | | |
| CI-994 (HDAC) | | | | | | | | | | | |
| Pleiotropin | | | | | | | | | | | |
| Gemcabene/CI-1027 | | | | | | | | | | | |
| CP-122,721 (Substance P) | | | | | | | | | | | |
| BAY-74-4113 (DGAT) | | | | | | | | | | | |
| AG-1859 (Protease Inhibitor for HIV) | | | | | | | | | | | |
| CP-866,087 | | | | | | | | | | | |
| AMF antibody (autocrine motility factor) | | | | | | | | | | | |
| Alpha-5-beta integrin | | | | | | | | | | | |
| PF-190,424 (cardiology) | | | | | | | | | | | |
| PF-489,781 (HTN) | | | | | | | | | | | |
| begacestat | | | | | | | | | | | |
| sulopenem | | | | | | | | | | | |
| CE-224,535 | | | | | | | | | | | |
| bapineuzumab | | | | | | | | | | | |
| Aprela (bazedoxifene+estrogen) | Menopause | Estrogen | LGND | III | | | | | | | |
| PF-00299804 (dacomitinib) | NSCLC | Pan-HER | 1 | III | Tykerb, Herceptin | | 9/30/2008 advanced | | | | |
| PF-03882845 | Diabetic Nephropathy | Mineralocorticoid antagonist | 1 | I | | | | | | | |
| PF-05231023 | Type 2 Diabetes | Undisclosed | 1 | I | | | | | | | |
| PF-05190457 | Type 2 Diabetes | Ghrelin | 1 | I | | | | | | | |
| CVX-096 (PF-04856883) | Type 2 Diabetes | GLP1 | 1 | I | | | | | | | |
| OAP-189 (PF-05212389) | Type 2 Diabetes | Oxyntomodulin | 1 | I | Biologic. Previously listed as GLP1? | | | | | | |
| PF-04991532 | Type 2 Diabetes | Unknown | 1 | II | | | | | | | |
| PF-868554 (filibuvir) | Hepatitis C | Polymerase | 1 | II | Roche | Oral | Disclosed 7/31/2007 | | | | |
| IMA-638 (anrukinzumab) | Ulcerative Colitis | IL-13 Antibody | 1 | II | | | Discontinued 11/8/13 | | | | |
| PF-03049423 | Stroke Recovery | PDE5 | 1 | II | | | Discontinued 11/8/13 | | | | |
| PF-04691502 | Cancer | mTOR/PI3K | 1 | II | NVGN, ARIA, NVS | | | | | | |
| PF-04856884/CVX-060 | Cancer | Ang2 | 1 | II | | | | | | | Failures |
| PF-05236806/ACC-001 | Alzheimer's | A-Beta Vaccine | 1 | II | | | | | | | |
| PF-04382923 | AMD | Undisclosed | 1 | I | | | | | | | |
| PF-04605412 | Cancer | Integrin | 1 | I | | | | | | | |
| PF-04531083 | Pain | Undisclosed | 1 | I | | | | | | | |
| PF-04427429 | Migraine | CGRP Antibody | 1 | I | | | | | | | |
| PF-05180999 | Schizophrenia | | 1 | I | | | | | | | |
| RN317/PF-05335810 | Dyslipidemia | | | | | | | | | | |
| PF-06305591 | Pain | I | | | | | | | | | |
| Remoxy | Pain | Opioid | PTIE | Filed | Purdue? | | | | | | |
| tanezumab | Pain | NGF Antibody | 1 | III | | | 2/28/14 Updated | | | | |
| PH-797804 | COPD | p38 | 1 | II | | Oral | 2/28/14 Updated | | | | |
| bococizumab RN316 (PF-04950615) | Hypercholesterolemia | PCSK9 | 1 | III | | SQ | 2/28/14 Updated | | | | |
| PD-0360324 | Sarcoidosis, Lupus | MCSF Mab | 1 | II | | | 2/28/14 Updated | | | | |
| PF-00547659 (ontamalimab) | Crohn's, Ulcerative Colitis | MadCAM Antibody | 1 | II | | | 2/28/14 Updated | Divested to Takeda | | | |
| PF-06290510 | Staph Aureus | Vaccine | 1 | II | | | 2/28/14 Updated | | | | |
| PF-02545920 | Schizophrenia | PDE10A | 1 | II | | | 2/28/14 Updated | | | | |
| PF-04236921 | Crohn's, Lupus | IL-6 Antibody | 1 | II | | | 2/28/14 Updated | | | | |
| PF-05285401 | Ulcerative Colitis | Multistem | ATHX | II | | | 2/28/14 Updated | | | | |
| PF-06473871 (EXC-001) | Dermal Scarring | CTGF | 1 | II | Acquired from Excalliard. Phase II reported? | | 2/28/14 Updated | | | | |
| PF-04171327 | RA | GR agonist | 1 | II | | | 2/28/14 Updated | | | | |
| PF-04937319 | Type 2 Diabetes | Glucokinase | 1 | II | | | 2/28/14 Updated | | | | |
| PF-05175157 | Type 2 Diabetes | Acetyl-CoA carboxylase | 1 | II | | | 2/28/14 Updated | | | | |
| PF-04634817 | Diabetic Nephropathy | CCR2/5 | 1 | II | | | 2/28/14 Updated | | | | |
| PF-00489791 | Diabetic Nephropathy | PDE5 | 1 | II | Positive POC, was HTN/PAH. | | 2/28/14 Updated | | | | |
| PF-04360365 (ponezumab) | Cerebral Amyloid Angiopathy | Beta Amyloid | 1 | II | | | 2/28/14 Updated | | | | |
| PF-05212384 | Cancer | mTOR/PI3K | 1 | II | | | 2/28/14 Updated | | | | |
| PF-03446962 | Cancer | ALK1 mab | 1 | II | | | 2/28/14 Updated | | | | |
| PF-05089771 | Pain | Nav1.7 | 1 | I | | | 2/28/14 Updated | | | | |
| PD-0325901 | Cancer | MEK | 1 | I | | | 2/28/14 Updated | | | | |
| Dekavil | RA | | Philogen | I | | | 2/28/14 Updated | | | | |
| PF-05230907 | Intracerebral Hemorrhage | Biologic | 1 | I | | | 2/28/14 Updated | | | | |
| PF-05082566 | Cancer | 4-1BB | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06687859 | SMA | Decapping Enzyme | Repligen | I | | | 2/28/14 Updated | | | | |
| PF-06252616 | Muscular Dystrophy | Myostatin | 1 | I | | | 2/28/14 Updated | | | | |
| PF-05280602 | Hemophilia | Biologic | 1 | I | | | 2/28/14 Updated | | | | |
| PF-03715455 | COPD | Undisclosed | 1 | I | | | 2/28/14 Updated | | | | |
| PF-05402536 | Smoking Cessation | | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06425090 | C. Difficile | | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06263276 | Psoriasis | | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06263507 | Cancer | | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06444752 | Asthma | IGGE Vaccine | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06480605 | Crohn's | | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06342674 | Type 1 Diabetes | | 1 | I | | | 2/28/14 Updated | | | | |
| PF-04958242 | Schizophrenia | AMPA | 1 | I | | | 2/28/14 Updated | | | | |
| PF-05212377 (SAM-760) | Alzheimer's | 5HT6 | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06649751 | Parkinson | | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06372865 | Pain | | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06273340 | Pain | | 1 | I | | | 2/28/14 Updated | | | | |
| PF-05236812 (AAB-003) | Alzheimer's | Abeta Vaccine | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06291874 | Type 2 Diabetes | | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06282999 | ACS | | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06678552 | Hypercholesterolemia | | 1 | I | | | 2/28/14 Updated | | | | |
| PF-06438179 | Rheumatoid Arthritis | Biosimilar Remicade | 1 | I | | | 2/28/14 Updated | | | | |
| PF-03084014 | Cancer | Gamma Secretase | 1 | I | | | 2/28/14 Updated | | | | |