A	B	C
1	Main
2		Generic Name	pertuzumab
3		Indication	mBC.
4		Mechanism	HER-2 dimerisation inhibitor
5		Clinical Trials
6			Phase III 1L mBC CLEOPATRA - January 2008 initiation
7
8			Phase II NEOSPHERE - P+H+Chemo vs H+Chemo in aBC - Presented at SABCS 2010
9			46% doublet vs 29% single.
10
11			Phase II Herceptin+pertuzumab open-label? in refractory Herceptin mBC patients.
12			8% CR, 16% PR, 25% SD.