A	B	C	D	E	F	G	H	I	J
1	Main
2		Brand	Generic	FDA Approval	MOA	Indication	Form	Company	Peak Revenue	Notes
3		Desoxyn	methamphetamine	12/31/1943	DAT inhibitor	ADHD	tablet	Key	25
4		Ritalin	methylphenidate	12/5/1955	DAT inhibitor	ADHD	tablet	NVS	400
5		Atarax	hydroxyzine	4/12/1956	H1 antagonist	Anxiety	tablet	PFE	50
6		Thorazine	chlorpromazine	11/20/1957	D2 antagonist	Schizophrenia	tablet	GSK	50	Antipsychotic activity discovered in 1952
7		Tofranil	imipramine	10/2/1959	SNRI	Depression	injection	NVS	50
8		Adderall	amphetamine aspartate, sulfate, dextroamphetamine saccharate, sulfate	1/19/1960	DAT inhibitor	ADHD	tablet		200
9		Librium	chlordiazepoxide	2/24/1960	GABA agonist	Anxiety	capsule		50
10		Prolixin	fluphenazine	8/24/1960	D2 antagonist	Schizophrenia	tablet		50
11		Parnate	tranylcypromine	2/21/1961	MAO	Depression	tablet		50
12		Elavil	amitriptyline	4/7/1961	MAO	Depression	tablet		100
13		Nardil	phenelzine	6/9/1961	MAO	Depression	tablet	PFE	50
14		Mellaril	thioridazine	3/15/1962	D2 antagonist	Schizophrenia	tablet	NVS	50
15		Valium	diazepam	11/15/1963	GABA agonist	Anxiety	tablet		200
16		Serax	oxazepam	6/4/1965	GABA agonist	Anxiety			50
17		Tegretol	carbamazepine	3/11/1968	Na+ channel blocker	Bipolar Disorder	tablet	NVS	400
18		Sinequan	doxepin	9/23/1969	MAO	Depression	capsule	PFE	50
19		Lithonate, Lithobid	lithium carbonate	4/6/1970	Unknown	Bipolar Disorder			50
20		Narcan	naloxone	4/13/1971	opioid receptor antagonist	Opioid Use Disorder	injection		50
21		Haldol	haloperidol lactate	5/18/1971	D2 antagonist	Schizophrenia		JNJ	200	Used in the 1960s?
22		Moban	molindone	1/18/1974	D2 antagonist	Schizophrenia	tablet, capsule		50
23		Klonopin	clonazepam	6/4/1975	GABA agonist	Anxiety		ROG	200
24		Centrax	prazepam	1976??	GABA agonist	Anxiety		PFE	50
25		Dexedrine	dextroamphetamine sulfate	8/2/1976	DAT inhibitor	ADHD	capsule		50
26		Pamelor	nortriptyline	8/1/1977	MAO	Depression	capsule		50
27		Ativan	lorazepam	9/30/1977	GABA agonist	Anxiety	tablet		100
28		Depakene	valproic acid	2/28/1978	GABA agonist	Bipolar Disorder	capsule	ABBV	100
29		Xanax	alprazolam	10/16/1981	GABA agonist	Anxiety		PFE	200
30		Depakote	divalproex	3/10/1983	GABA agonist	Bipolar Disorder	tablet	ABBV	300
31		Seconal	secobarbital	10/3/1983	GABA agonist	Anxiety			50
32		Orap	pimozide	7/31/1984	D2 antagonist	Schizophrenia	tablet	TEVA?	50
33		Revia	naltrexone	11/20/1984	opioid receptor antagonist	Opioid Use Disorder	tablet		50
34		Doral	quazepam	12/27/1985	GABA agonist	Anxiety			50
35		Wellbutrin	bupropion	12/30/1985	NDRI	Depression	tablet	GSK	1000
36		Buspar	buspirone	9/29/1986	5-HT1A	Anxiety		BMY	300
37		Prozac	fluoxetine	12/29/1987	SSRI	Depression		LLY	1000
38		Clozaril	clozapine	9/26/1989	D2 antagonist	Schizophrenia	tablet	NVS	100
39		Anafranil	clomipramine	12/29/1989	MAO	Depression	capsule		50
40		Zoloft	sertraline	12/30/1991	SSRI	Depression	tablet	PFE	1000
41		Ambien	zolpidem	12/16/1992	GABA agonist	Insomnia	tablet	SNY	1000
42		Paxil	paroxetine	12/29/1992	SSRI	Depression	tablet	GSK	1000
43		Effexor	venlafaxine	12/28/1993	SNRI	Depression	tablet	PFE (Wyeth)	500
44		Risperdal	risperidone	12/29/1993	D2 antagonist	Schizophrenia		JNJ	4000
45		Lamictal	lamotrigine	12/27/1994	Na+ antagonist	Bipolar Disorder		GSK	1500
46		Remeron	mirtazapine	6/14/1996	5HT2A antagonist	Depression	tablet	ORG	200
47		Zyprexa	olanzapine	9/30/1996	D2 antagonist	Schizophrenia		LLY	5000
48		Depacon	valproate	12/30/1996	GABA agonist	Bipolar Disorder	injection	ABBV	200
49		Zyban	bupropion	5/14/1997	NDRI	Smoking Cessation	tablet	GSK	200
50		Seroquel	quetiapine	9/26/1997	D2 antagonist	Schizophrenia		AZN	4000
51		Celexa	citalopram	7/17/1998	SSRI	Depression	tablet	Forest (Abbvie/Actavis)	1000
52		Provigil	modafinil	12/24/1998	DAT inhibitor	ADHD	tablet	CEPH	1000
53		Concerta	methylphenidate	8/1/2000	DAT inhibitor	ADHD	tablet	JNJ	1000
54		Geodon	ziprasidone	2/5/2001	D2 antagonist	Schizophrenia	capsule	PFE	1000
55		Adderall XR	amphetamine aspartate, sulfate, dextroamphetamine saccharate, sulfate	10/11/2001	DAT inhibitor	ADHD	capsule	SHPGY	1000
56		Lexapro	escitalopram	8/14/2002	SSRI	Depression	tablet	Forest (Abbvie/Actavis)	1000
57		Abilify	aripiprazole	11/15/2002	D2 antagonist	Schizophrenia	tablet	BMY/Otsuka	6000
58		Strattera	atomoxetine	11/26/2002	NRI	ADHD	capsule	LLY	1000
59		Risperdal Consta	risperidone	10/29/2003	D2 antagonist	Schizophrenia	injection	JNJ/ALKS	1000
60		Cymbalta	duloxetine	8/3/2004	SNRI	Depression	capsule	LLY	4000
61		Lunesta	eszopiclone	12/15/2004	GABA agonist	Insomnia	tablet	SEPR	500
62		Rozerem	ramelteon	7/22/2005	MT1/MT2 inhibitor	Insomnia	tablet	TAK	200
63		Vivitrol	naltrexone	4/13/2006	opioid receptor antagonist	Alcohol Use Disorder	injection	ALKS	400
64		Chantix	varenicline	5/10/2006	nicotinic antagonist	Smoking Cessation	tablet	PFE	1000
65		Invega	paliperidone	12/19/2006	D2 antagonist	Schizophrenia	tablet	JNJ	100
66		Vyvanse	lisdexamfetamine	2/23/2007	DAT inhibitor	ADHD	capsule	Takeda/Shire/New River	3200
67		Nuvigil	armodafinil	6/15/2007	DAT inhibitor	ADHD	tablet	CEPH	500
68		Pristiq	desvenlafaxine	2/29/2008	SNRI	Depression	tablet	PFE	500
69		Aplenzin	bupropion	4/23/2008	NDRI	Depression	tablet		50
70		Fanapt	iloperidone	5/6/2009	D2 antagonist	Schizophrenia	tablet	VNDA	100
71		Invega Sustenna	paliperidone palmitate	7/31/2009	D2 antagonist	Schizophrenia	injection	JNJ	3000
72		Saphris	asenapine	8/13/2009	D2 antagonist	Schizophrenia	tablet	AGN	200
73		Intuniv	guanfacine	9/2/2009	Alpha-2 agonist	ADHD	tablet	SHPGY	100
74		Suboxone	buprenorphine, naloxone	8/30/2010	opioid receptor antagonist	Opioid Use Disorder	sublingual	INDV	200
75		Latuda	lurasidone	10/28/2010	D2 antagonist	Schizophrenia	tablet	4506 JP	1000
76		Viibryd	vilazodone	1/21/2011	SSRI	Depression	tablet	ABBV	200
77		Quillivant	methylphenidate	9/27/2012	DAT inhibitor	ADHD	suspension	PFE	100
78		Trintellix	vortioxetine	9/30/2013	SSRI	Depression	tablet	TAK	715
79		Belsomra	suvorexant	8/13/2014	Orexin	Insomnia	tablet	MRK	500
80		Invega Hafyera	paliperidone palmitate	5/18/2015	D2 antagonist	Schizophrenia	injection	JNJ	3000
81		Invega Trinza	paliperidone palmitate	5/18/2015	D2 antagonist	Schizophrenia	injection	JNJ	3000
82		Rexulti	brexpiprazole	7/10/2015	D2 partial agonist	Schizophrenia	tablet	Otsuka	500
83		Vraylar	cariprazine	9/17/2015	D2 antagonist	Schizophrenia	capsule	ABBV/AGN	3000
84		Quillichew	methylphenidate	12/4/2015	DAT inhibitor	ADHD	tablet	PFE	100
85		Nuplazid	pimavanserin	4/29/2016	5HT2A antagonist	Parkinson's Psychosis	tablet	ACAD	1000
86		Lucemyra	lofexidine	5/16/2018	Alpha-2 agonist	Opioid Use Disorder	tablet	US World Meds	100
87		Spravato	esketamine	3/5/2019	NMDA	Depression	Intranasal	JNJ	500
88		Dayvigo	lembrorexant	12/20/2019	Orexin	Insomnia	tablet	4523 JP	200
89		Caplyta	lumateperone	12/20/2019	D2 antagonist	Schizophrenia	capsule	ICPT	1000
90		Azstarys	dexmethylphenidate, serdexmethylphenidate	3/2/2021	DAT inhibitor	ADHD	capsule	Commave	100
91		Qelbree	viloxazine	4/2/2021	NET inhibitor	ADHD	capsule	SUPN	100
92		Lybalvi	olanzapine/samidorphin	5/28/2021	D2 antagonist	Schizophrenia	tablet	ALKS	100
93		Quviviq	daridorexant	1/7/2022	Orexin	Insomnia	tablet	IDIA	100
94		Auvelity	bupropion / dextromethorphan	8/18/2022	NDRI	Depression	tablet	AXSM	100
95
96		Could not find/honorable mentions/unclassified
97		Dalmine	zopiclone
98		Restoral	propranolol
99		Traxene