A	B	C	D	E	F	G	H	I	J	K	L	M	N	O	P	Q	R	S	T	U	V	W	X	Y	Z	AA	AB	AC	AD	AE	AF	AG	AH	AI	AJ	AK	AL	AM	AN	AO	AP	AQ	AR	AS	AT	AU	AV	AW	AX	AY	AZ	BA	BB	BC	BD	BE	BF	BG	BH	BI	BJ	BK	BL	BM	BN	BO	BP	BQ	BR	BS	BT	BU	BV	BW	BX	BY	BZ	CA	CB	CC	CD	CE	CF	CG	CH	CI	CJ	CK	CL	CM	CN	CO
1	Main
2			Q110	Q210	Q310	Q410	Q111	Q211	Q311	Q411		2008	2009	2010	2011	2012	2013	2014	2015	2016	2017	2018	2019	2020	2021	2022
3		Myelofibrosis US Prevalence					27000	27000	27000	27000		27000	27000	27000	27000	27810	28644.3	29503.629	30388.73787	31300.4000061	32239.412006283	33206.594366471494	34202.79219746564	35228.87596338961	36285.7422422913	37374.31450956004
4		Diagnosed and Treatment-Eligible					18900	18900	18900	18900		18900	18900	18900	18900	19467	20051.01	20652.5403	21272.116509	21910.28000427	22567.5884043981	23244.616056530045	23941.95453822595	24660.213174372726	25400.019569603908	26162.020156692026
5		Penetration					0.005	0.02	0.04	0.06		0	0	0	0.0875	0.2	0.25	0.3	0.35	0.4	0.45	0.1	0.05	0.05	0.05	0.05
6		# pts					94.5	378	756	1134		0	0	0	2362.5	5562	7161.075	8851.0887	10636.0582545	12520.160002440001	14507.735402827351	3320.6594366471495	1710.139609873282	1761.4437981694807	1814.2871121145652	1868.7157254780022
7		424 Price					100	100	100	100		100	100	100	100	105	110.25	115.7625	121.55062500000001	127.62815625000002	134.00956406250003	134.00956406250003	134.00956406250003	134.00956406250003	134.00956406250003	134.00956406250003
8		424 Revs					9.45	37.8	75.6	113.4		0	0	0	236.25	584.01	789.5085187499999	1024.62415563375	1292.8195283708842	1597.924937066413	1944.1752968669916	445.00012350511145	229.1750636051324	236.0503155132864	243.13182497868502	250.42577972804557
9		Myelofibrosis ex-US Prevalence					27000	27000	27000	27000		27000	27000	27000	27000	27540	28090.8	28652.615999999998	29225.668319999997	29810.1816864	30406.385320128	31014.51302653056	31634.80328706117	32267.499352802395	32912.84933985845	33571.106326655616
10		Diagnosed and Treatment-Eligible					13500	13500	13500	13500		13500	13500	13500	13500	13905	14322.15	14751.8145	15194.368935	15650.20000305	16119.7060031415	16603.297183235747	17101.39609873282	17614.437981694806	18142.87112114565	18687.15725478002
11		Penetration					0	0	0	0		0	0	0	0	0.05	0.1	0.15	0.2	0.25	0.3	0.35	0.4	0.45	0.5	0.05
12		# pts					0	0	0	0		0	0	0	0	1377	2809.08	4297.8924	5845.133664	7452.5454216	9121.9155960384	10855.079559285696	12653.921314824469	14520.374708761077	16456.424669929223	1678.5553163327809
13		424 Price					100	100	100	100		100	100	100	100	100	100	100	100	100	100	100	100	100	100	100
14		424 Revs					0	0	0	0		0	0	0	0	137.7	280.908	429.78924	584.5133664	745.2545421599999	912.19155960384	1085.5079559285696	1265.3921314824468	1452.0374708761076	1645.6424669929224	167.8555316332781
15		Royalty Rate					0.1	0.1	0.1	0.1		0.1	0.1	0.1	0.1	0.1	0.15	0.15	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2
16		Royalty Revs					0	0	0	0		0	0	0	0	13.77	42.1362	64.468386	116.90267328	149.050908432	182.438311920768	217.10159118571391	253.07842629648937	290.40749417522153	329.1284933985845	33.571106326655624
17
18
19
20		Contract revs	16737	49737	16737	85737	85737	85737	85737	85737		659	5755	168948	342948	5000	5000	5000	5000	5000	5000	5000	5000	5000	5000	5000
21		License & royalty revs	551	110	135	133	133	133	133	133		3260	3510	929	532	200	200	200	200	200	200	200	200	200	200	200
22		424 Revenues	0	0	0	0	9450	37800	75600	113400		0	0	0	236250	597780	831644.7187499999	1089092.54163375	1409722.2016508842	1746975.8454984128	2126613.608787759	662101.7146908253	482253.48990162177	526457.8096885079	572260.3183772695	283996.8860547012
23		Total revenues	17288	49847	16872	85870	95320	123670	161470	199270		3919	9265	169877	579730	602980	836844.7187499999	1094292.54163375	1414922.2016508842	1752175.8454984128	2131813.608787759	667301.7146908253	487453.48990162177	531657.8096885079	577460.3183772695	289196.8860547012
24		COGS	0	0	0	0	0.4725	1.89	3.78	5.670000000000001		0	0	0	11.8125	29889	41582.235937499994	54454.627081687504	70486.11008254421	87348.79227492065	106330.68043938797	33105.085734541266	24112.67449508109	26322.8904844254	28613.01591886348	14199.844302735059
25		R&D	31439	28883	30609	32774	33429.48	34098.0696	34780.030992	35475.63161184		146362	119442	123705	137783.21220384	137783.21220384	137783.21220384	137783.21220384	137783.21220384	137783.21220384	137783.21220384	68891.60610192	68891.60610192	68891.60610192	68891.60610192
26		SG&A	5794	7485	8458	10765	11518.550000000001	12324.848500000002	13187.587895000002	14110.719047650004		17073	27580	32502	51141.70544265001	52675.95660592951	54256.235304107395	55883.92236323062	57560.44003412754	59287.253235151366	61065.87083220591	30532.935416102955	27479.64187449266	24731.677687043393	22258.509918339056	20032.65892650515
27		Total expenses	37233	36368	39067	43539	44948.50250000001	46424.8081	47971.398887	49592.02065949		163435	147022	156207	188936.73014649	220348.1688097695	233621.6834454474	248121.7616487581	265829.76232051174	284419.257713912	305179.76347543387	132529.6272525642	120483.92247149374	119946.1742733888	119763.13193912254	34232.50322924021
28		Operating Income	-19945	13479	-22195	42331	50371.49749999999	77245.1919	113498.601113	149677.97934051		-159516	-137757	13670	390793.26985350996	382631.8311902305	603223.0353045525	846170.779984992	1149092.4393303725	1467756.5877845008	1826633.8453123253	534772.0874382611	366969.567430128	411711.6354151191	457697.186438147	254964.38282546095
29		Interest, other	-15457	-10104	-10164	-9789	-9789	-9789	-9789	-9789		-19404	-74113	-45514	-39156	-39156	-39156
30		Pretax Income	-35402	3375	-32359	32542	40582.49749999999	67456.1919	103709.601113	139888.97934051		-178920	-211870	-31844	351637.26985350996	343475.8311902305	564067.0353045525	846170.779984992	1149092.4393303725	1467756.5877845008	1826633.8453123253	534772.0874382611	366969.567430128	411711.6354151191	457697.186438147	254964.38282546095
31		Tax	327	331	-658	0	0	23609.667165	36298.36038955	48961.1427691785		0	0	0	108869.1703237285	120216.54091658066	197423.46235659337	296159.77299474715	402182.35376563034	513714.80572457524	639321.8458593138	187170.2306033914	128439.34860054479	144099.07239529167	160194.01525335142	89237.53398891132
32		Net Income	-35729	3044	-31701	32542	40582.49749999999	43846.524735000006	67411.24072345	90927.83657133151		-178920	-211870	-31844	242768.09952978147	223259.29027364985	366643.5729479592	550011.0069902448	746910.0855647421	954041.7820599256	1187311.9994530114	347601.8568348697	238530.2188295832	267612.5630198275	297503.17118479556	165726.84883654962	157440.50639472212	149568.48107498602	142090.05702123672	134985.55417017487	128236.27646166613	121824.46263858282	115733.23950665367	109946.57753132097	104449.24865475492	99226.78622201717	94265.4469109163	89552.17456537049	85074.56583710195	80820.83754524685	76779.7956679845	72940.80588458526	69293.765590356	65829.07731083818	62537.623445296274	59410.74227303146	56440.20515937988	53618.19490141088	50937.28515634034	48390.42089852332	45970.899853597155	43672.354860917294	41488.737117871424	39414.30026197785	37443.58524887895	35571.405986435006	33792.83568711326	32103.193902757594	30498.034207619712	28973.132497238727	27524.475872376788	26148.25207875795	24840.83947482005	23598.797501079047	22418.857626025092	21297.914744723836	20233.019007487645	19221.36805711326	18260.299654257597	17347.284671544716	16479.920437967477	15655.924416069103	14873.128195265648	14129.471785502365	13422.998196227245	12751.848286415881	12114.255872095087	11508.543078490333	10933.115924565816	10386.460128337525	9867.137121920648	9373.780265824616	8905.091252533386	8459.836689906717	8036.84485541138	7635.002612640811	7253.25248200877	6890.589857908331	6546.060365012914	6218.757346762268	5907.819479424154	5612.428505452946	5331.807080180299
33		Earnings per share	-0.2984205734713139	0.023727307449470346	-0.2594423393267806	0.26464225883577575	0.3283882904816224	0.3400736047025554	0.5202403182066778	0.6982363952652362		-1.992760483376956	-2.0581292559960365	-0.26181471371723614	1.8954581267386112	1.725880580868317	2.820195511852017	4.230644385530421	5.7451776779561206	7.338419518038571	9.132716946604438	2.6737280260365286	1.8347569743974546	2.0584562360536895	2.28837260501002	1.2747587841899914
34		Shares out	119727	128291	122189	122966	123580.82999999999	128932.45499999999	129577.11727499997	130225.00286137496		89785	102943	121628	128078.85128409372	129359.63979693466	130006.43799591932	130006.43799591932	130006.43799591932	130006.43799591932	130006.43799591932	130006.43799591932	130006.43799591932	130006.43799591932	130006.43799591932	130006.43799591932
35
36		Cash & equiv	404746	414088	388804	424168						178767	449824	424168														Maturity	-0.05
37		Marketable securities	17494	8102	6781							19257	20594	0														Discount	0.15
38		Restricted cash	19045	18980	18993							0	19032	0														NPV	2655264.7103621415
39		Accts receivable	5253	6360	4735							1050	163661	0														Share	21.76446483903395
40		Prepaid expenses, other	4269	3763	3232							6420	2944	0
41		Total current assets	450807	451293	422545							205494	656055	0
42		Marketable securities	14	0	0							19759	3513	0
43		Restricted cash	37447	28267	28375							0	37191	0
44		Property & equip	1808	2159	2385							2796	1752	0
45		Other	12587	11962	11335							4339	13879	0
46		Total assets	502663	493681	464640	489581						232388	712390	489581
47
48		Accts payable	13304	9158	7750							15679	20964	0
49		Accrued comp	7842	8019	10920							9330	13418	0
50		Interest payable	9553	4750	9500							5273	7094	0
51		Other current liabilities	14537	17740	20708							14893	17441	0
52		Deferred rev	67020	67000	66980							62	67030	0
53		Accrued restructuring	5688	4277	1664							5100	6879	0
54		Total current liabilities	117944	110944	117522							50337	132826	0
55		Convert sr notes	261408	266304	271315	276445						130969	308059	276445
56		Convert subord notes	16292	16521	16753	16987						265198	135079	16987
57		Deferred rev	221432	204695	187958							0	238169	0
58		Other liabilities	0	0	0							6634	641	0
59		Total liabilities	617076	598464	593548							453138	814774	0
60		SE	-114413	-104783	-128908	-88644						-220750	-102384	-88644
61		Total liabilities & SE	502663	493681	464640	489581						232388	712390	489581
62
63		Net loss	-35729	3044	-31701	32542							-211870	-31844
64		Non-cash restructuring	-115	-145	-139	-120							2011	-519
65		D&A	6396	5885	5378	5500							16690	23159
66		Stock-based comp	3121	3555	4059	4500							9980	15235
67		Loss on embedded deriv liability	0	0	0	0							34300	15235
68		Loss/impair on repurchase of notes	3988	0	0	0							5727	0
69		Realized loss/gain investments	0	0	134	0							1339	134
70		Change in working capital	125162	-15105	-7252	0							154181	102805
71		Cash fr operating activities	102823	-2766	-29521	42422							12358	124205
72		Cap ex	-306	-598	-466	-500							-387	-1870
73		Marketable securities	6822	10272	1321	0							16839	18415
74		Other	0	0	0	0							0	0
75		Cash fr investing activities	6516	9674	855	-500							16452	16545
76		Stock fr plans	4227	2434	3383	4000							2061	14044
77		Issuance of common stock	0	0	0	0							132336	0
78		Change in restricted cash	0	0	0	0							-56223	0
79		Repurchase/proceeds fr notes	-158644	0	0	0							164080	-158644
80		Cash fr financing activities	-154417	2434	3383	4000							242254	14044
81		Change in cash	-45078	9342	-25283	45922							271064	154794
82		Beginning cash	449824	404746	414088	388805							178767	449824
83		Ending cash	404746	414088	388805	434727							449824	604618