A	B	C	D	E	F	G	H	I	J	K	L	M	N	O	P	Q	R	S	T	U	V	W	X
1	Main
2		Brand Name	Imitrex
3		Generic Name	Sumatriptan
4		Mechanism	Selective 5-ht1 agonist (no 5-ht2, etc.)
5			Mediates vasoconstriction
6		Administration	Oral tablet, subcutaneous injection, nasal spray
7
8			Oral Tablet
9
10				Pain Relief at 2 Hours				Pain Relief at 4 Hours
11				Placebo	25mg	50mg	100mg	Placebo	25mg	50mg	100mg
12			Study 1	0.27	0.52	0.61	0.62	0.38	0.67	0.78	0.79
13			Number of Patients (N)	94	298	296	296	94	298	296	296
14			Study 2	0.26	0.52	0.5	0.56	0.38	0.7	0.68	0.71
15			Number of Patients (N)	65	66	62	66	65	66	62	66
16			Study 3	0.17	0.52	0.54	0.57	0.19	0.65	0.72	0.78
17			Number of Patients (N)	47	48	46	46	47	48	46	46
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37			Subcutaneous Injection
38
39				Placebo	1mg	2mg	3mg	4mg	6mg	8mg
40			Number of Patients (N)	62	30	30	30	30	30	30
41			Relief (10 min)	0.05	0.1	0.07	0.17	0.13	0.1	0.23
42			Relief (30 min)	0.15	0.4	0.23	0.47	0.37	0.63	0.57
43			Relief (1 hr)	0.24	0.43	0.57	0.57	0.5	0.73	0.8
44			Relief (2 hr)	0.21	0.4	0.43	0.6	0.57	0.7	0.83
45			Adverse Events Incidence	0.55	0.63	0.63	0.77	0.8	0.83	0.93
46
47				Study 1		Study 2
48				Placebo	6mg	Placebo	6mg
49				n=190	n=384	n=180	n=350
50			1-Hour Data
51			Pain Relief (grade 0/1)	0.18	0.7	0.26	0.7
52			No Pain	0.05	0.48	0.13	0.49
53			Without Nausea	0.48	0.73	0.5	0.73
54			Without Photophobia	0.23	0.56	0.25	0.58
55			Little or No Clinical Disability	0.34	0.76	0.34	0.76
56			2-Hour Data
57			Pain Relief (grade 0/1)	0.31	0.81	0.39	0.82
58			No Pain	0.11	0.63	0.19	0.65
59			Without Nausea	0.56	0.82	0.63	0.81
60			Without Photophobia	0.31	0.72	0.35	0.71
61			Little or No Clinical Disability	0.42	0.85	0.49	0.84
62
63
64			Nasal Spray
65
66				placebo	5mg	10mg	20mg
67			Headache Response (2 hrs)
68			Study 1	0.25	0.49	0.46	0.64
69			Number of Patients (N)	63	121	112	118
70			Study 2	0.25	n/a	0.44	0.55
71			Number of Patients (N)	138		273	277
72			Study 3	0.35	n/a	0.54	0.63
73			Number of Patients (N)	100		106	202
74			Study 4	0.29	n/a	0.43	0.62
75			Number of Patients (N)	112		106	215
76			Study 5	0.36	0.54	0.53	0.6
77			Number of Patients (N)	198	296	291	286
78			Adverse Events
79			Number of Patients (N)	704	496	1007	1212
80			Burning Sensation	0.001	0.004	0.006	0.014
81			Sinus Discomfort	0.024	0.028	0.025	0.038
82			Throat Discomfort	0.009	0.008	0.018	0.024
83			Nausea/Vomiting	0.113	0.122	0.11	0.135
84			Dizziness	0.009	0.01	0.017	0.014
85			Taste	0.017	0.135	0.193	0.245
86			Information Source: Imitrex Nasal Spray Prescribing Information
87
88
89
90		£ millions	1Q04A	2Q04A	3Q04A	4Q04A	1Q05A	2Q05A	3Q05A	4Q05A	1Q06A	2Q06E	3Q06E	4Q06E		2003	2004	2005	2006	2007	2008	2009	2010	2011
91		- USA	126	109	127	130	123	112	131	138	135	130	123.48	105.44		560	492	504	493.92	390	234	140.4	84.24	50.544
92		- Europe	35	36	36	35	33	37	36	38	37	37.5	37.5	38		146	142	144	150	148.5	147.015	145.54485	144.0894015	142.648507485
93		- RoW	11	13	12	12	11	13	13	12	10	12.1275	12.1275	14.255		53	48	49	48.51	48.024899999999995	47.544650999999995	47.06920449	46.5985124451	46.132527320649