ABC
1Main
2Brand NamePromacta (US), Revolade (EU)
3Generic Nameeltrombopag
4IndicationITP
5Mechanismoral platelet growth factor
6CompetitionNplate (AMG531, Amgen). May have more durable responses than Nplate.
7Approval10/10 Japan approval.
83/12/10 EU approval.
912/18/09 EMEA positive opinion.
10Clinical Trialsp2 data 6/19/06 shows 81% of patients achieving primary endpoint (>50k/micro liter after up to 6wks) vs 11% for placebo after "up to 6 weeks" of dosing
11data presented at EHA
12ASCO 2006
13oral platelet growth factor increases platelet counts in thrombocytopenic patients and healthy subjects