A	B	C	D	E	F	G	H	I	J	K	L
1	Main
2		Brand Name	Aciphex. Known as Pariet in ROW.
3		Generic Name	rabeprazole delayed release
4		Indication	GERD, Heartburn, Peptic Ulcer
5		Administration	Oral
6		Mechanism	PPI
7		Economics	Eisai co-promotion -- what are the details?
8		Timeline	Filed 3/31/1998, approved 8/19/1999.
9		IP	5/8/2013 found to be enforceable, Teva loses case. 30-Month stay expires February 2007. 20mg delay release tablet being sued by TEVA, RDY and MYL
10		Competition	Nexium (AZN), Prilosec (generic OTC), Protonix (WYE), Zantac (OTC), Axid (generic), Prevacid (Takeda/Abbott).
11		Rx
12			2001	2002	2003	2004	2005	2006	2007	2008	2009	2010
13		US
14		ROW
15		WW		697	966	1116	1169	1239	1357	1158	1096
16
17
18		Clinical Trials
19			Phase 3 GERD study vs placebo
20			At week 4, 63% of 10mg were healed vs 56% for 20mg, 54% for 40mg and 0% placebo.
21			Comparing across trials, Protonix label notes 46%, 58% and 75% healing rates for 10mg, 20mg and 40mg with 14% for placebo.
22			At week 8, 93% of 10mg were healed vs 84% for 20mg, 85% for 40mg and 12% for placebo.
23			Comparing across trials, Protonix label notes 66%, 84% and 93% cure rates for 10mg, 20mg and 40mg vs 40% placebo.
24
25			Phase 3 GERD study vs ranitidine (Zantac)
26			At week 4, 59% were healed vs 36% for Zantac.
27			Comparing across trials, Protonix label notes 61% and 64% cure rates vs 22% for Axid.
28			At week 8, 87% were healed vs 66% for Zantac.
29			Comparing across trials, Protonix label notes 79% and 83% cure rates vs 41% for Axid.
30
31
32
33		Rx
34		10/31/2008
35		10/24/2008
36		10/17/2008	133726
37		10/10/2008	137437
38		10/3/2008	142546
39		9/26/2008	139554
40		9/19/2008	136830
41		9/12/2008	138729
42		9/5/2008	132066
43		8/29/2008	140859
44		8/22/2008	135720
45		8/15/2008	134693