A | B | C | |
---|---|---|---|
1 | Main | ||
2 | Brand | Darzalex | |
3 | Generic | daratumumab | |
4 | Indication | Multiple Myeloma. 68k patients treated in the US | |
5 | MOA | CD38 mab | |
6 | Economics | Genmab. Licensing deal 8/2012. | |
7 | IP | ||
8 | Clinical Trials | ||
9 | Phase II "GRIFFIN" D-RVd vs. RVd n=207 post-ASCT consolidation MM, NCT02874742 | ||
10 | sCR 42.4% vs 32%, p=0.068 | ||
11 | PFS HR=0.45, p=0.0324, median PFS not reached | ||
12 | MRD negativity 64% vs 30% |